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Ray M. Kaplan (contact information  )                                                     

Ray M. Kaplan, DVM, PhD, DipEVPC
Associate Professor
Department of Infectious Diseases
College of Veterinary Medicine
University of Georgia
Athens, Georgia  30602



 

 

 

Full curriculum vitae and contact information 

 
Dr. Kaplan is an Associate Professor in the Department of Infectious Diseases in the College of Veterinary Medicine at the University of Georgia.  Prior to his position at University of Georgia, Dr. Kaplan served in the Army Veterinary Corps at the Walter Reed Army Institute of Research where he was Chief of Parasite Biology in the Division of Experimental Therapeutics.  Dr. Kaplan received his bachelor’s degree from Virginia Tech and his DVM from Virginia-Maryland Regional College of Veterinary Medicine.  He worked as a clinical veterinarian in a mixed-species private practice in Pennsylvania for several years before leaving practice for the University of Florida where he earned a PhD in Veterinary Parasitology.  Since 1998 he has been in his current position where he teaches and performs research in veterinary and human medical parasitology.  Dr. Kaplan is principal investigator and director of the Filariasis Research Reagent Resource Center (FR3), and is director of the Athens Parasitology Diagnostic Laboratory.

The primary research focus of his laboratory is to measure, understand, and solve the problems presented by drug-resistant parasites.   Over the past forty years, the availability of cheap and effective anthelmintic drugs has led to an almost complete reliance on these chemicals for parasite control in animals. Chemical-based parasite control was extremely effective for many years, but we now know that this strategy has turned out to be shortsighted and unsustainable. Parasite drug resistance is now recognized globally as one of the greatest health threats to grazing livestock.  Also, in recent years there has been a dramatic increase in the use of mass drug administration to reduce the morbidity associated with helminth parasite infections of humans, raising the likelihood that anthelmintic resistance may become a public health concern in the near future.

To address these problems, Dr. Kaplan’s laboratory pursues research projects with several different areas of emphasis:

1. Measuring the prevalence of drug resistance
2. Studying the molecular basis of anthelmintic resistance
3. Developing molecular diagnostic assays to detect emerging resistance in nematode populations
4. Developing and optimizing in vitro diagnostic assays to detect and measure clinically relevant levels of anthelmintic resistance
5. Studying and developing novel and sustainable approaches to parasite control that deemphasize chemical control
6. Developing improved methods for evaluating and understanding fecal egg count data, especially as relating to diagnosing resistance using the fecal egg count reduction test
 

Recent Publications

Mortensen, L.L., L.H. Williamson ,  T.H. Terrill, R. Kircher, M. Larsen and R.M. Kaplan. 2003.     Evaluation of prevalence and clinical implications of anthelmintic resistance in gastrointestinal nematodes of goats.  JAVMA, 223(4):495-500.

Terrill, T.H., M. Larsen, O. Samples, S. Husted, J.E. Miller,
R.M. Kaplan, S. Gelaye.  2004. Capability of the nematode-trapping fungus Duddingtonia flagrans to reduce infective larvae of gastrointestinal nematodes in goat feces in the southeastern United States: dose titration and dose time interval studies, Veterinary Parasitology, 120, (4), 285-96.

Tandon, R., and
R.M. Kaplan. 2004.  Evaluation of a larval development assay (DrenchRite®) for the detection of anthelmintic resistance in cyathostomin nematodes of horses. Veterinary Parasitology, 121: 125-142.

Kaplan, R.M., T.R. Klei, E.T. Lyons, G.D. Lester, D.D. French, S.C. Tolliver, C.H. Courtney, Y. Zhao, and A. Vidyashankar. 2004.  Prevalence of anthelmintic resistant cyathostomes on horse farms. JAVMA, 225(6): 903-910.

Kaplan, R.M., and J.B. Mathews.  2004. Equine Cyathostomins, in (Eds.) Williams, J.C., Gasser, R., and Malone, J.B., Diversity and Progress of Veterinary Parasitology Research in the 21st Century.  A selection of presentations given during the 19th International Conference of the World Association for the Advancement of Veterinary Parasitology (WAAVP): Veterinary Parasitology,125 (1-2):  203-220.

Kaplan, R.M., J.M. Burke, T.H. Terrill,  J.E. Miller, W.R. Getz, S. Mobini, E. Valencia, M.J.Williams, L.H. Williamson, M. Larsen, and A.F. Vatta.  2004. Validation of the FAMACHA© eye color chart for detecting clinical anemia in sheep and goats on farms in the southern United States. Veterinary Parasitology 123: 105-120.

Kaplan, R.M.  2004. Drug resistance in nematodes of veterinary importance: a status report. Trends in Parasitology 20(10): 477-481. [Identified by Essential Science Indicators to be one of the most cited papers in the research area of “DRUG RESISTANCE.”
(see http://sciencewatch.com/sciencewatch/dr/erf/2008/08aprerf/08aprerfKap/])

Stuedemann, J.A.,
R.M. Kaplan, H. Ciordia, A. J. Franzluebbers, T. B. Stewart, and D. H. Seman. 2004.  Bermudagrass management in the Southern Piedmont USA: V. Gastrointestinal parasite control in cattle. Veterinary Parasitology, 126: 375-385.

Clark, H.J.,
R.M. Kaplan, J.B. Matthews and J.E. Hodgkinson  2005.  Isolation and characterisation of a beta tubulin isotype 2 gene from two species of cyathostomin.  International Journal for Parasitology 35:4, 349-358.

Tandon, R., E. T. Lyons, Tolliver, S.C.,
Kaplan, R.M.  2005. Effect of moxidectin selection on the genetic variation within Cylicocyclus nassatus based on amplified fragment length polymorphism (AFLP). International Journal for Parasitology 35(7): 813-819.

Fleming, S A.,T. Craig,
R.M. Kaplan, J. E. Miller, C. Navarre, M. Rings.  2006.  Consensus Statement on: Anthelmintic resistance of gastrointestinal parasites in small ruminants. Journal of Veterinary Internal Medicine, 20:435–444.

Shaika, S.A., T.H. Terrill, J.E. Miller, B. Kouakou, G. Kannan,
R.M. Kaplan, J. Burke, and J. Mosjidis 2006.  Use of sericea lespedeza hay as a natural deworming agent in goats infected with Haemonchus contortus. Veterinary Parasitology, 139:150–157.

van Wyk, J.A,. H. Hoste,
R.M. Kaplan, R.B. Besier 2006.  Targeted selective treatment for worm management - how do we sell rational programs to farmers? Veterinary Parasitology,139:336-346.

Tandon, R., K.T. LePage, and
R.M. Kaplan  2006.  Cloning and characterization of genes encoding alpha and beta subunits of glutamate-gated chloride channel protein in Cylicocyclus nassatus. Molecular and Biochemical Parasitology, 150:46-55.

Schwenkenbecher, J.M. and
Kaplan, R.M.  2007.  Development and characterization of microsatellite markers for the canine hookworm, Ancylostoma caninum. Parasitology Research, 100:1015-1021.

Kaplan, R.M., A. N. Vidyashankar, S.B. Howell, J.M. Neiss, L.H. Williamson, and T.H. Terrill. 2007.  A novel approach for combining the use of in vitro and in vivo data to measure and detect emerging moxidectin resistance in gastrointestinal nematodes of goats. International Journal for Parasitology, 37:795-804.

Burke, J.M.,
R.M. Kaplan, J.E. Miller, T.H. Terrill, W.R. Getz, S. Mobini, E. Valencia, M.J. Williams, L.H. Williamson and A.F. Vatta.  2007. Accuracy of the FAMACHA system for on-farm use by sheep and goat producers in the southeastern United States. Veterinary Parasitology 147:89-95.

Nielsen, M.K.,
R.M. Kaplan, S.M.Thamsborg, J. Monrad, and S.N. Olsen.  2007. Climatic influences on development and survival of free-living stages of equine strongyles: Implications for worm control strategies and managing anthelmintic resistance.  The Veterinary Journal, 174:23-32.

Schwenkenbecher, J.M., M. Albonico, B. Quentin,
R.M. Kaplan. 2007.  Characterization of beta-tubulin genes in hookworms and investigation of resistance-associated mutations using real-time PCR. Molecular and Biochemical Parasitology, 156:167-174.

Vidyashankar, A.N.,
R.M. Kaplan, S. Chan.  2007. Statistical approach to measure efficacy of anthelmintic treatment on horse farms, Parasitology, 134:2027-2039.

Nielsen, M.K., D.S. Peterson, J. Monrad, S.M. Thamsborg, SN. Olsen,
R.M. Kaplan. 2008. Detection and semi-quantification of Strongylus vulgaris DNA in equine faeces by real-time PCR. International Journal for Parasitology, 38:443-453.

Hodgkinson, J.E., H. J. Clark,
R.M. Kaplan, S.L.Lake, J.B. Matthews.  2008.  The role of polymorphisms at beta tubulin isotype 1 codons 167 and 200 in benzimidazole resistance in cyathostomins, International Journal for Parasitology, 38:1149-1160.

Howell, S.B., J.M. Burke, J.E. Miller, T.H. Terrill, E. Valencia , M.J. Williams, L.H. Williamson, A.M. Zajac,
R.M. Kaplan. 2008. Anthelmintic resistance on sheep and goat farms in the southeastern United States, JAVMA, accepted.
 
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